Beilstein J. Org. Chem.2013,9, 1002–1011, doi:10.3762/bjoc.9.115
of the analogous fluoroacetamide.
Keywords: fluorine-18; hydrolytic metabolism; prostheticgroups; radiochemistry; sulfonamides; Introduction
The importance of molecular imaging, i.e., the characterisation and measurement of biological processes in living organisms at the molecular level using
to be modified with fluorine. For this purpose, generic groups that allow both derivatisation with fluorine as well as convenient introduction of radiofluorine are often used. These groups are referred to as prostheticgroups in preparative radiochemistry. For labelling with fluorine-18, a variety of
prostheticgroups were suggested and developed [5][6]. Their careful individual selection is critical for radiotracer development as they often exert great influence on target binding and/or stability in vivo. This is particularly valid when PET imaging probes based on small molecules are considered
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Graphical Abstract
Figure 1:
Selection of prosthetic agents for 18F-labelling via acylation.